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肺非小細胞癌患者における血漿Matrix Metalloproteinase(MMP)-9上昇とその産生部位の検討：飯笹俊彦,藤澤武彦,鈴木実,尾辻瑞人,柴光年,馬場雅行（千葉大・肺癌研）

Elevated plasma concentration of MMP-9 in non small cell lung cancer (NSCLC): Toshihiko IIZASA, Takehiko FUJISAWA, Makoto SUZUKI, Mizuto OTSUJI, Mitsutoshi SHIBA, Masayuki BABA (Dept. of Surgery, Inst. of Pulmonary Cancer Res., Chiba Univ. School of Med.)

We investigated correlations of plasma concentration of MMP-9 with expression of it in tumor samples and other clinical features in patients with NSCLC. A series of 73 operated cases (45 men and 28 women) was used. Histologic types included 38 adenoca., 25 squamous cell ca., 8 large cell ca., and 2 adeno-squamous cell ca.. Preoperative plasma concentration of MMP-9 were measured with a one-step sandwich enzyme immunoassay. The expressions of MMP-2 and 9, tissue inhibitor of MMP (TIMP)-1, and TIMP-2 were confirmed in 24 tumor samples immunohisto-chemically. The plasma concentration MMP-9 in the patients with NSCLC (71.0±60.2 ng/ml) was significantly elevated than that of healthy volunteers (P<.0001). The concentrations of MMP-9 were elevated in 33/73 cases (45.2%) compared with a mean + 2SD in healthy volunteers. There were significant differences in adenoca. vs squamous cell ca. (P=.014) and adenoca. vs large cell ca. (P=.014). Five of 24 patients (20.8%) had positive staining in cytoplasm of tumor cells for MMP-9, and two cases had been positive in surrounding stromal cells. The elevation of plasma concentration of MMP-9 does not appear to correlate with production from cancer cells and stromal cells.