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精巣腫瘍における転移予知因子としてのVEGFの発現：福田聡一郎¹、白浜勉¹、今園義治¹、西山賢龍¹、秋葉澄伯²、大井好忠¹（¹鹿児島大学・泌尿器科、²鹿児島大学・公衆衛生）

Overexpression of Vascular endothelial growth factor (VEGF) in Testicular germ cell tumors as an Indicator of metastatic Disease: Souichirou FUKUDA¹, Tsutomu SHIRAHAMA¹, Yoshiharu IMAZONO¹, Kenryu NISHIYAMA¹,Suminori AKIBA², Yoshitada OHI¹ (¹Dept. of Urology, ²Dept. of Public Health, Faculty of Medicine, Kagoshima Univ.)

Tumor angiogenesis is considered essential for tumor growth and metastasis. We analyzed expression of angiogenic factors, VEGF and thymidine phosphorylase(TP), in germ cell tumors (GCT) and their association with angiogenesis and metastatic disease.Tissues were obtained from the tumors of 45 patients whose tumors were limited to the testis and 35 who had metastasis. Microvessel counts and expressions of VEGF and TP were assessed by immunostaining. Expression of VEGF was also examined by immunoblot analysis. Immunoblot analysis showed that expression of VEGF was significantly higher in carcinoma tissues than in non-carcinoma tissues. Microvessel density was significantly higher in VEGF-positive carcinoma tissues than in VEGF-negative carcinoma tissues (p ＜0.001). Multiple regression analysis using VEGF expression and other histological findings showed that VEGF expression was an independent predictive factor of metastatic disease (p =0.006 ). In contrast,TP was strongly expressed in stromal cells that might be macrophages and fibroblasts, but not cancer cells. These findings suggest that VEGF overexpression in GCT is related to angiogenesis and the occurrence of metastatic disease.