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子宮頚癌におけるPD-ECGFの発現とその意義：関　典子、児玉順一、徳毛敬三、山田詞奈子、中村圭一郎、河西邦浩、山本順子、本郷淳司、宮木康成、吉野内光夫、工藤尚文（岡山大・医・産婦）

Platelet-derived endothelial cell growth factor is implicated in progression in cervical cancer: Noriko SEKI, Junichi KODAMA, Keizo TOKUMO, Shinako YAMADA, Keiichiro NAKAMURA, Kunihiro KAWANISHI, Junko YAMAMOTO, Atsushi HONGO, Yasunari MIYAGI, Mitsuo YOSHINOUCHI and Takafumi KUDO ( Dept. Obst. Gyne., Okayama Univ. Med. Sch.)

The association between the expression of platelet-derived endothelial cell growth factor (PD-ECGF) and clinico-pathological factors have scarcely been examined in cervical cancer. The object of this study was to examine the level of PD-ECGF mRNA expression in invasive cervical cancer tissues and its association with clinicopathological features including microvessel density. The level of VEGF mRNA was assessed by semi-quantitative RT-PCR using β-actin as an internal control in 47 patients with invasive cervical cancers. In 31 patients who underwent radical hysterectomy and pelvic lymphadenectomy, the microvessel count was also assessed by immunostaining for factor VIII-related antigen in the most neovascularized area of the specimen. Advanced stage of the disease disclosed a significantly higher PD-ECGF mRNA levels (p<0.01). Squamous cell carcinomas expressed significantly higher levels of PD-ECGF mRNA than non-squamous cell carcinomas (P<0.01). The cases with deep stromal invasion or positive surgical margins showed a significantly higher PD-ECGF mRNA levels (p<0.05). There were no significant differences in PD-ECGF mRNA levels with respect to tumor size, lymph node metastasis, lymph-vascular space involvement, parametrial involvement or vaginal involvement. There was no correlation between microvessel count and the levels of PD-ECGF mRNA. These findings suggested that PD-ECGF expression is closely associated with progression of cervical cancer.