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Ezrin, a Membrane-Cytoskeletal Linking Protein, is Involved in the Process of Invasion and Metastasis of Human Endometrial Cancer Cells : Kaori OHTANI, Hideki SAKAMOTO, Hiroho OHTA, Takashi SHIRAKAWA, Yasuo NAKAYAMA, Kazuo SATOH (Dept. of Obstet. and Gynecol., Nihon Univ. Sch. Med.)

Ezrin, a membrane-cytoskeletal linking protein, was identified by immunohistochemistry at much higher levels in gynecologic cancers than in non-cancerous tissues. Cancer cells found in invasive and metastatic lesions showed much stronger ezrin expression than cells in the primary lesion. The specific antiserum for human placental ezrinハand ezrin antisense oligonucleotides inhibited cellular invasion but not proliferation of both low- and highly-metastatic endometrial cancer cells. In this assay, cells that attached to or penetrated into Matrigel showed a shift of ezrin molecule from the cytoplasm to the membrane. Ezrin was overexpressed in highly-metastatic endometrial cancer cells at only the protein level and not the mRNA level. Ezrin expression is required for cell invasion. Post-transcriptional up-regulation of ezrin is involved in the acquisition of the metastatic potential in human endometrial cancer cells.