ABSTRACT 2589(P17-1)
膵癌と喫煙：矼暎雄１、菊地正悟２、黒澤美智子２（１浅間総合病院・健管、２順天堂大・医・衛生）
Pancreatic cancer and smoking：Teruo ISHIBASHI１, Shogo KIKUCHI２, Michiko KUROSAWA２（１Section of Health Administ, Asama General Hosp.,２Dept. Epidemiol. Juntendo Univ. Scho. of Med.
Purpose: To investigate risk factors for incidence of pancreatic cancer. Subjects & methods: Subjects were from 28,000 residents over 35 years of age, living in Saku-city, Nagano, who responded to the questionnaire on habits, food and past history in January '89. Incidence cases were those who were newly diagnosed as pancreatic cancer between January '92 and March '97. The information on the incidence was obtained from cancer registry in this area. As to each factor, sex and age adjusted hazard ratio for the cancer was calculated. In addition to age and sex, factors whose p-values were less than 0.05 in the analyses were put into a proportional hazard model, and the final model was obtained by backward elimination so that all p-values of the factors except sex and age were less than 0.10. Results: Number of the incidence cases was 36. Results are shown below. Discussion: Both cheese and smoking elevated the risk of pancreatic cancer. Those, who intake cheese frequently, tend to intake a lot of fat and protein and may have high risk for pancreatic cancer. Smoking increases carcinogenic substances in the blood and in the pancreatic juice, which may play a role in pancreatic carcinogenesis.
Explanatory variables Hazard ratio(95%CI) p-value
Age +1 year 1.09 (1.06, 1.13) p<0.001
Sex Male 1.0 p=0.227
Female 1.66 (0.73, 3.77)
Body mass index +1 0.93 (0.85, 1.04) p=0.087
Cheese 0-2 times/month 1.0 p=0.017
1+ times/week 3.08 (1.42, 6.66)
Unknown 1.82 (0.78, 4.25)
Cigarettes /day 0-4 1.0 p=0.038
5+ 3.10 (1.30, 7.39)
Unknown 1.26 (0.29, 5.44)