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肺腺がんにおける肺内炭粉沈着量の検討：方　明¹，森下由紀雄²，飯島達生²，野口雅之¹（¹筑波大学基礎医学系病理　²付属病院病理）

Carbon Particle Deposition and Pulmonary adenocarcinoma: Mei HOU¹, Yukio MORISHITA², Tatsuo IIJIMA², and Masayuki NOGUCHI¹. (¹Dept. of Pathol., Inst. of Basic Med. Sci., ²Dept. of Pathol., Univ. Hosp., Univ. of Tsukuba )

The relationship betweenthe deposition of carbon particle in the lung parenchyma and the development of pul onary adenocarcinoma has not been fully characterized. In order to clarify the role or significance of background carbon particle deposition in the development and progression of pulmonary adenocarcinoma, we measured the level of anthracosis in 47 autopsied patients who had died of pulmonary adenocarcinoma.
The bilateral lungs of the 47 autopsy cases were examined. Twenty-micrometer sections were cut from formalin-fixed, paraffin-embedded blocks of the largest cut surface of the bilateral lungs. Carbon particles were extracted from the sections and blotted onto the nitrocellulose membrene. The density of the blotted carbon particles was then analyzed using an imaging densitometer.
There were no significant differences in the density of carbon particale deposition between the lungs affected by pulmonary adenocarcinoma and control lungs. Howerer, among the cases examined, well differentiated adenocarcinomas tended to develop more frequently in lungs showing less deposition than poorly differentiated adenocarcinomas (p<0.05). We found a very strong correlation between the degree of carbon particle depositon and smoking history or degree of the background fibrosis in the lungs. The cases with severe anthracosis tended to have a poorer prognosis than those associated with mild anthracosis (p<0.05),