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IQの低用量及び高用量投与によるSCIDマウス大腸における変異クリプト巣の誘発. サリム エリサイド，鰐渕英機，山本晋史，森村圭一朗，須方督夫，福島昭治

Site-specific induction of aberrant crypt foci in the colons of female and male SCID mice after administration of low and high doses of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) .
Elsayed I. SALIM, Hideki WANIBUCHI, Shinji YAMAMOTO, Keiichirou MORIMURA, Tokuo SUKATA and Shoji FUKUSHIMA. First Dept. Pathol. Osaka City Univ. Medical School.
We applied an approach to an assessment of the carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in SCID mice. In experiment I, 60 female and male, 8 weeks old, mice were administered 50, 10, 2 and 0 ppm of IQ in the diet for 30 weeks for the females and 23 weeks for the males. The induction of ACF in colons of both females and males was dose dependent. The incidence of ACF was; 100, 100 and 63% in 50 ppm, 10 ppm and 2 ppm in females and 100, 83 and 63% in males respectively. ACF were found to be accumulated mainly in proximal colons of both females and males. In experiment II, administration of 300 and 100 ppm doses of IQ for 20 weeks to male SCID mice, showed that 62% and 74% of ACF were induced in proximal colons of 300 ppm and 100 ppm treated mice respectively. BrdU incorporation in the colonic crypts of the proximal colons of IQ treated mice showed significant increase as compared to middle and distal colons and controls. No lesions were detected in other organs of the treated mice. The results indicate that IQ may find application for colon carcinogenesis in the SCID mice.