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I3Ｃ, α-NFのPhIP誘発ラット乳腺発癌への修飾効果:K. M. Wahidur RAHMAN¹, 杉江茂幸^1,2, 酒々井夏子¹, 牛田淳¹, Pham Quang VINH¹, 森秀樹¹（¹岐阜大・医・病理、²動物実験施設）

Modifying Effect of Indole-3-Carbinol or α- Naphthoflavone on 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced Mammary Carcinogenesis in Rats: K. M. Wahidur RAHMAN¹, Shigeyuki SUGIE^1,2, Natsuko SUZUI¹, Jun USHIDA¹, Pham Quang VINH¹, Hideki MORI¹ (¹Dept. Pathol., ²Institute of Laboratory Animals, Gifu Univ. Sch. of Med.)

Modifying effects of indole-3-carbinol (I3C),protocatechuic acid (PCA) and α- naphthoflavon (α- NF) on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)-induced mammary carcinogenesis in SD rats were investigated. A total of 176 female rats, 6 weeks old, were divided into eight groups. They were fed high fat diet throughout the experiment. Starting at 7 weeks of age, groups 1-4 were given PhIP (85mg/kg body weight in corn oil) by gavage 8 times in 14 days and groups 5-8 were given corn oil alone. After the start of the experiment of 4 weeks , groups 2 and 5 were given I3C at 1000ppm in diet. Similarly groups 3 and 6, and groups 4 and 7 were given PCA (2000ppm) and α-NF (1000ppm), respectively. Mammary carcinomas were only recognized in group 1-4 at the termination (24 weeks after the start of experiment). Final incidences of total tumors were 62.5%, 38.2%, 58.8% and 36.4% in groups 1-4, respectively. Although the incidences of groups 2 and 4 were rather lower than that of group 1, the differences was not significant. At the end of experiment, the average number of total tumors were 1.75±2.24, 1.09±1.83, 1.47±2.40 and 0.76±1.32 in group 1-4, respectively. The multiplicity of total tumors were significantly decreased by a- NF. These result indicate that dietary intake of I3C or a- NF during the time of corresponding to initiation phase has chemopreventive potential on PhIP- induced mammary carcinogenesis in rats.