ポスターセッション

一覧　トップ

大腸癌におけるThrombospondin 遺伝子の発現とその意義：中村雅登,徳永徹二,大鹿芳郎,土田　孝,鬼島　宏,山崎　等,上山義人,玉置憲一（東海大・医・病理）

Thrombospondin-2 expression inhibit angiogenesis and metastasis of colon cancer : Masato NAKAMURA, Tetsuji TOKUNAGA,Yoshiro OSHIKA, Takashi TSUCHIDA, Hiroshi KIJIMA, Hitoshi YAMAZAKI, Yoshito UEYAMA, Norikazu TAMAOKI (Dept. of Pathology, Tokai Univ. Sch. of Med.)

Two subtypes of thrombospondin (TSP1 and TSP2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP1 and TSP2 gene expression by RT-PCR analysis in 61 colon cancers in association with VEGFisoform pattern. Thirty-eight of these 61 colon cancers were positive for TSP2 expression and showed hepatic metastasis at a significantly lower incidence than those without TSP2 expression (P = 0.02). TSP2- / VEGF189+ colon cancers showed significantly increased vessel counts density in the stroma (P < 0.0001) and poorer prognosis as compared to those with TSP2+ / VEGF189-(P = 0.0014). These results suggest that colon cancer metastasis is critically determined by angiogenesis resulting from the balance between the angioinhibitory factor TSP2 and angiogenic factor VEGF189.