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非小細胞肺癌におけるThrombospondin2遺伝子の発現とその意義：大鹿芳郎,中村雅登,徳永徹二,鬼島　宏,山崎　等,上山義人,玉置憲一（東海大・医・病理）

Thrombospondin 2 gene expression in non-small cell lung cancer：Yoshiro OSHIKA, Masato NAKAMURA, Tetsuji TOKUNAGA, Hiroshi KIJIMA, Hitoshi YAMAZAKI, Yoshito UEYAMA, Norikazu TAMAOKI (Dept. of Pathology, Tokai Univ. Sch. of Med.)

Stromal vascularity is thought to be a major factor involved in the progression of carcinoma. Thrombospondin (TSP) has an inhibitory role against vascularization in vitro, although the biological significance of TSP has not been characterized in vivo. We examined expression of TSP1 and TSP2 genes in 78 non-small cell lung cancers (NSCLC) and 33 extra-neoplastic lung tissue samples by RT-PCR. TSP1 expression was detected in 66.7% of NSCLC and in 69.7 % of extraneoplastic lung tissue specimens. TSP2 expression was seen in 48.7% of NSCLC, while 72.7% of extraneoplastic lung tissue samples showed TSP2 gene expression. TSP2 expression was significantly decreased in NSCLC as compared to extra-neoplastic lung tissue. Vascularity in the NSCLC was inversely correlated with TSP2 gene expression. Patients with adenocarcinoma positive for TSP2 gene expression showed significantly better prognosis than those without TSP2 . TSP1 expression showed no apparent correlation with these factors. These results suggested that TSP2 had an inhibitory role against vascularization and progression of NSCLC.